Landscape of IDH1/2 mutations in Chinese patients with solid tumors: A pan-cancer analysis.

ABSTRACT:

Background

Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. However, the landscape of IDH mutations in pan-cancer has not been fully characterized.

Methods

Tissue or blood samples were subjected to next-generation sequencing (NGS) for detection the IDH mutation.

Results

A total of 28.868 patients from more than 20 solid tumor species were analyzed. A total of 374 cases (1.30%) with IDH mutations were identified. Among all the IDH mutations cases, 80 (21.4%) were biliary tract cancer (BTC), 80 (21.4%) were lung cancer, 57 (15.2%) were liver cancer, and 42 (11.2%) were colorectal cancer. The most common IDH variant were IDH1 and IDH2 which were discovered in 0.81% cases and 0.47% cases, respectively. How

SUBMITTER: Shen D 

PROVIDER: S-EPMC8404228 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature