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Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology.

ABSTRACT: Paeonol, derived from natural plants (Moutan Cortex), has a wide range of biological effects, including anti-inflammatory and antitumor effects as well as favorable effects against cardiovascular and neurodegenerative diseases. The anti-inflammatory action is the main pharmacological activity of paeonol and has the greatest clinical relevance. However, the anti-inflammatory mechanism of paeonol has not been reported in sufficient detail. We systematically analyzed the anti-inflammatory mechanism of paeonol using network pharmacological databases and platforms, including TCMSP, Swiss TargetPrediction, OMIM, DrugBank, TTD, Jevnn, STRING11.0, and Metascape. Furthermore, we used high-throughput molecular docking method to prove the results of the above analyses, providing a reference for exploring the mechanism of paeonol and developing targeted drugs.

SUBMITTER: Qi JH

PROVIDER: S-EPMC8405392 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology.

Qi Jian-Hong JH Dong Fang-Xu FX Wang Xiao-Long XL

Molecular diversity 20210831 3

Paeonol, derived from natural plants (Moutan Cortex), has a wide range of biological effects, including anti-inflammatory and antitumor effects as well as favorable effects against cardiovascular and neurodegenerative diseases. The anti-inflammatory action is the main pharmacological activity of paeonol and has the greatest clinical relevance. However, the anti-inflammatory mechanism of paeonol has not been reported in sufficient detail. We systematically analyzed the anti-inflammatory mechanism ...[more]

PMID: 34463943

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