Unknown

Dataset Information

0

Programming ultrasensitive threshold response through chemomechanical instability.


ABSTRACT: The ultrasensitive threshold response is ubiquitous in biochemical systems. In contrast, achieving ultrasensitivity in synthetic molecular structures in a controllable way is challenging. Here, we propose a chemomechanical approach inspired by Michell's instability to realize it. A sudden reconfiguration of topologically constrained rings results when the torsional stress inside reaches a critical value. We use DNA origami to construct molecular rings and then DNA intercalators to induce torsional stress. Michell's instability is achieved successfully when the critical concentration of intercalators is applied. Both the critical point and sensitivity of this ultrasensitive threshold reconfiguration can be controlled by rationally designing the cross-sectional shape and mechanical properties of DNA rings.

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC8405678 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4902157 | biostudies-literature
| S-EPMC4595639 | biostudies-other
| S-EPMC8025675 | biostudies-literature
| S-EPMC5785464 | biostudies-literature
| S-EPMC6364638 | biostudies-literature
| S-EPMC7423358 | biostudies-literature
2018-01-15 | GSE98183 | GEO
| S-EPMC10761733 | biostudies-literature
| S-EPMC6353092 | biostudies-literature
| S-EPMC8358272 | biostudies-literature