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Programming ultrasensitive threshold response through chemomechanical instability.

ABSTRACT: The ultrasensitive threshold response is ubiquitous in biochemical systems. In contrast, achieving ultrasensitivity in synthetic molecular structures in a controllable way is challenging. Here, we propose a chemomechanical approach inspired by Michell's instability to realize it. A sudden reconfiguration of topologically constrained rings results when the torsional stress inside reaches a critical value. We use DNA origami to construct molecular rings and then DNA intercalators to induce torsional stress. Michell's instability is achieved successfully when the critical concentration of intercalators is applied. Both the critical point and sensitivity of this ultrasensitive threshold reconfiguration can be controlled by rationally designing the cross-sectional shape and mechanical properties of DNA rings.

SUBMITTER: Kim YJ

PROVIDER: S-EPMC8405678 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Programming ultrasensitive threshold response through chemomechanical instability.

Kim Young-Joo YJ Park Junho J Lee Jae Young JY Kim Do-Nyun DN

Nature communications 20210830 1

The ultrasensitive threshold response is ubiquitous in biochemical systems. In contrast, achieving ultrasensitivity in synthetic molecular structures in a controllable way is challenging. Here, we propose a chemomechanical approach inspired by Michell's instability to realize it. A sudden reconfiguration of topologically constrained rings results when the torsional stress inside reaches a critical value. We use DNA origami to construct molecular rings and then DNA intercalators to induce torsion ...[more]

PMID: 34462430

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