Unknown

Dataset Information

0

Aberrant levels of cortical myelin distinguish individuals with depressive disorders from healthy controls.


ABSTRACT: The association between depressive disorders and measures reflecting myelin content is underexplored, despite growing evidence of associations with white matter tract integrity. We characterized the T1w/T2w ratio using the Glasser atlas in 39 UD and 47 HC participants (ages = 19-44, 75% female). A logistic elastic net regularized regression with nested cross-validation and a subsequent linear discriminant analysis conducted on held-out samples were used to select brain regions and classify patients vs. healthy controls (HC). True-label model performance was compared against permuted-label model performance. The T1w/T2w ratio distinguished patients from HC with 68% accuracy (p < 0.001; sensitivity = 63.8%, specificity = 71.5%). Brain regions contributing to this classification performance were located in the orbitofrontal cortex, anterior cingulate, extended visual, and auditory cortices, and showed statistically significant differences in the T1w/T2w ratio for patients vs. HC. As the T1w/T2w ratio is thought to characterize cortical myelin, patterns of cortical myelin in these regions may be a biomarker distinguishing individuals with depressive disorders from HC.

SUBMITTER: Baranger DAA 

PROVIDER: S-EPMC8406024 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5785483 | biostudies-literature
| S-EPMC5828008 | biostudies-literature
| S-EPMC9127936 | biostudies-literature
| S-EPMC7416601 | biostudies-literature
| S-EPMC4500934 | biostudies-literature
2012-08-01 | GSE18123 | GEO
| S-EPMC7264684 | biostudies-literature
| S-EPMC6490069 | biostudies-literature
| S-EPMC3773676 | biostudies-literature
| S-EPMC3423523 | biostudies-literature