Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC8406401 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Wang Biao B He Wei W Prosseda Philipp P PP Li Liang L Kowal Tia J TJ Alvarado Jorge A JA Wang Qing Q Hu Yang Y Sun Yang Y
EMBO reports 20210513 7
Lysosomal positioning and mTOR (mammalian target of rapamycin) signaling coordinate cellular responses to nutrient levels. Inadequate nutrient sensing can result in growth delays, a hallmark of Lowe syndrome. OCRL mutations cause Lowe syndrome, but the role of OCRL in nutrient sensing is unknown. Here, we show that OCRL is localized to the centrosome by its ASH domain and that it recruits microtubule-anchoring factor SSX2IP to the centrosome, which is important in the formation of the microtubul ...[more]