Ontology highlight
ABSTRACT:
SUBMITTER: Siu KK
PROVIDER: S-EPMC8406655 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Siu Karen K KK Serrão Vitor Hugo B VHB Ziyyat Ahmed A Lee Jeffrey E JE
The Journal of cell biology 20210830 10
Fertilization is defined as the union of two gametes. During fertilization, sperm and egg fuse to form a diploid zygote to initiate prenatal development. In mammals, fertilization involves multiple ordered steps, including the acrosome reaction, zona pellucida penetration, sperm-egg attachment, and membrane fusion. Given the success of in vitro fertilization, one would think that the mechanisms of fertilization are understood; however, the precise details for many of the steps in fertilization r ...[more]