CXCR6 is required for antitumor efficacy of intratumoral CD8⁺ T cell.

ABSTRACT:

Background

Increasing infiltration of CD8⁺ T cells within tumor tissue predicts a better prognosis and is essential for response to checkpoint blocking therapy. Furthermore, current clinical protocols use unfractioned T cell populations as the starting point for transduction of chimeric antigen receptors (CARs)-modified T cells, but the optimal T cell subtype of CAR-modified T cells remains unclear. Thus, accurately identifying a group of cytotoxic T lymphocytes with high antitumor efficacy is imperative. Inspired by the theory of yin and yang, we explored a subset of CD8⁺ T cell in cancer with the same phenotypic characteristics as highly activated inflammatory T cells in autoimmune diseases.

Methods

Combination of single-cell RNA sequencing, general t

SUBMITTER: Wang B 

PROVIDER: S-EPMC8407215 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature