Dataset Information

Comparison of Viscoelastic Substance Injection Versus Air Filling in the Anterior Chamber During Foldable Capsular Vitreous Body (FCVB) Implant Surgery: A Prospective Randomized Controlled Trial.

ABSTRACT:

Introduction

To compare the outcomes of viscoelastic substance injection with air filling in the anterior chamber during foldable capsular vitreous body (FCVB) implant surgery in patients with severe retinal disease.

Methods

Thirty eyes with severe retinal diseases were randomly divided into two groups. In the viscoelastic group, 0.15-0.2 mL of 1.7% sodium hyaluronate was injected into the anterior chamber after FCVB implantation; in the air group, the anterior chamber was maintained by filling the air after FCVB implant surgery. The eyes of treated patients were examined during a 24-week follow-up appointment. Data, including intraocular pressure (IOP), the difference between preoperative and postoperative IOP, and postoperative complications, were recorded.

Results

Data collected from 27 eyes were used in the final analysis. The IOP of the air group was lower than that of the viscoelastic group from the first to third postoperative day (P < 0.01). Moreover, the difference between preoperative and postoperative IOP in the viscoelastic group was significantly smaller than that in the air group from the first to third postoperative day (P < 0.01). After the 1st postoperative week, postoperative IOP values were similar in the two groups (P > 0.05). Postoperative complications in the air group and the viscoelastic group included corneal blood staining (1 eye vs. 0 eyes), transient postoperative diffuse hemorrhage (5 eyes vs. 1 eye), inflammation reaction (9 eyes vs. 4 eyes), and postoperative fibrin exudation (4 eyes vs. 1 eye), respectively.

Conclusion

The use of viscoelastic substances in the anterior chamber during FCVB implant surgery was associated with less fluctuation in postoperative IOP and could reduce postoperative complications.

Registration number

ChiCTR-TNC-00000396.

SUBMITTER: Zhang Z

PROVIDER: S-EPMC8408088 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:PurposeTo evaluate the clinical effectiveness and safety of foldable capsular vitreous body (FCVB) implantation for severe retinal detachment.MethodsA retrospective analysis was performed on 26 patients with severe ocular trauma and one with recurrent retinal detachment. Clinical data-including surgery success, complications, retinal reattachment, vision, and intraocular pressure (IOP)-were analyzed for patients who underwent 23G pars plana vitrectomy and FCVB implantation combined with silicone oil tamponade.ResultsThe mean follow-up period was 10.44 ± 2.68 months. All surgeries were smooth; the FCVBs were properly positioned and supported the retina well, and the retinal reattachment rate reached 92.59%. At the six-month follow-up, preoperative (1.30 ± 1.20) and postoperative (0.63 ± 0.79) vision was significantly different (t = 3.03, P = 0.005), and the postoperative IOP (7.93 ± 3.57 mm Hg) was lower than the preoperative IOP (13.98 ± 10.72 mm Hg) (t = 2.74, P = 0.01). Among 20 patients followed up for >12 months, preoperative (1.20 ± 0.95) and postoperative (0.75 ± 0.91) visions were significantly different (t = 1.831, P = 0.005), and the postoperative IOP (9.85 ± 6.48 mm Hg) was lower than the preoperative IOP (14.85 ± 12.17 mm Hg) (t = 1.82, P = 0.01). No endophthalmitis, sympathetic ophthalmia, and rejection of FCVB occurred during follow-up.ConclusionsFCVB combined with silicone oil tamponade showed good efficacy and safety in severe retinal detachment treatment during the follow-up period.Translational relevanceVitreous substitution is deemed a highly challenging and interesting research topic in ophthalmology. Traditional method such as silicone oil tamponade often causes various complications such as silicone oil emulsification, silicone oil migration, and corneal degeneration. The foldable capsular vitreous body as a novel vitreous substitute combined silicone oil injection into it can stay in the eyeball for a long time without obvious complications.