Ontology highlight
ABSTRACT:
SUBMITTER: Brown MR
PROVIDER: S-EPMC8409580 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Brown Matthew R MR Holmes Heather H Rakshit Kuntol K Javeed Naureen N Her Tracy K TK Stiller Alison A AA Sen Satish S Shull Gary E GE Prakash Y S YS Romero Michael F MF Matveyenko Aleksey V AV
The Journal of clinical investigation 20210901 17
Pancreatic β cell failure in type 2 diabetes mellitus (T2DM) is attributed to perturbations of the β cell's transcriptional landscape resulting in impaired glucose-stimulated insulin secretion. Recent studies identified SLC4A4 (a gene encoding an electrogenic Na+-coupled HCO3- cotransporter and intracellular pH regulator, NBCe1) as one of the misexpressed genes in β cells of patients with T2DM. Thus, in the current study, we set out to test the hypothesis that misexpression of SLC4A4/NBCe1 in T2 ...[more]