Dataset Information

Contribution of abnormal BMI to adverse health-related quality of life outcomes after a 52-week long therapy in patients with SLE.

ABSTRACT:

Objectives

To investigate whether abnormal BMI is associated with adverse health-related quality of life (HRQoL) outcome, including severe fatigue, after 52 weeks of standard therapy (ST) plus belimumab or placebo in patients with SLE.

Methods

We analysed data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials (N = 1684). Adverse HRQoL was defined as SF-36 scores ≤ the 5th percentile in age- and sex-matched US population-based subjects, and FACIT-F scores <30. We compared BMI groups using the Pearson's χ2 test, and assessed independence with multivariable logistic regression analysis.

Results

Overweight (BMI ≥25 kg/m2) and obese (BMI ≥30 kg/m2) patients showed increased likelihood to exhibit adverse SF-36 physical component summary (OR: 1.8; 95% CI: 1.4-2.3; p< 0.001 and OR: 2.4; 95% CI: 1.8-3.2; p< 0.001, respectively) and FACIT-F (OR: 1.3; 95% CI: 1.1-1.6; p= 0.010 and OR: 1.5; 95% CI: 1.2-2.0; p= 0.002, respectively) scores at week 52. Underweight was associated with adverse SF-36 mental component summary scores, also after adjustment for sex, ancestry, age, disease duration, disease activity, organ damage and prednisone dose during the study period (OR: 2.1; 95% CI: 1.2-3.6; p= 0.007). Addition of belimumab to ST independently protected against adverse SF-36 general health (OR: 0.8; 95% CI: 0.6-1.0; p= 0.025) and FACIT-F < 30 (OR: 0.8; 95% CI: 0.6-1.0; p= 0.018).

Conclusion

Overweight and obesity contributed to adverse physical and mental HRQoL outcomes after therapeutic intervention in SLE patients, and underweight contributed to adverse mental HRQoL outcome. A protective effect of belimumab against adverse general health and severe fatigue was implicated.

SUBMITTER: Borg A

PROVIDER: S-EPMC8410008 | biostudies-literature |

REPOSITORIES: biostudies-literature

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