Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation.

ABSTRACT: The importance of (inherited) genetic impact in reading development is well established. De novo mutation is another important contributor that is recently gathering interest as a major liability of neurodevelopmental disorders, but has been neglected in reading research to date. Paternal age at childbirth (PatAGE) is known as the most prominent risk factor for de novo mutation, which has been repeatedly shown by molecular genetic studies. As one of the first efforts, we performed a preliminary investigation of the relationship between PatAGE, offspring's reading, and brain structure in a longitudinal neuroimaging study following 51 children from kindergarten through third grade. The results showed that greater PatAGE was significantly associated with worse reading, explaining an additiona

SUBMITTER: Xia Z 

PROVIDER: S-EPMC8410543 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature