Silicon-photomultiplier-based PET/CT reduces the minimum detectable activity of iodine-124.

ABSTRACT: The radioiodine isotope pair ¹²⁴I/¹³¹I is used in a theranostic approach for patient-specific treatment of differentiated thyroid cancer. Lesion detectability is notably higher for ¹²⁴I PET (positron emission tomography) than for ¹³¹I gamma camera imaging but can be limited for small and low uptake lesions. The recently introduced silicon-photomultiplier-based (SiPM-based) PET/CT (computed tomography) systems outperform previous-generation systems in detector sensitivity, coincidence time resolution, and spatial resolution. Hence, SiPM-based PET/CT shows an improved detectability, particularly for small lesions. In this study, we compare the size-dependant minimum detectable ¹²⁴I activity (MDA) between the SiPM-based Biograph Vision an

SUBMITTER: Kersting D 

PROVIDER: S-EPMC8410931 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature