Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.

ABSTRACT: Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure. A possible mechanism leading to multiple organ failure is hypoxia- or inflammation-induced down-regulation of the detoxifying glyoxalase system that clears dicarbonyl stress. The dicarbonyl methylglyoxal (MGO) is a highly reactive agent produced by metabolic pathways such as anaerobic glycolysis and gluconeogenesis. MGO leads to protein damage and ultimately multi-organ failure. Whether detoxification of MGO into D-lactate by glyoxalase functions appropriately under conditions of hypoxia and inflammation is largely unknown. We investigated the effect of inflammation and hypoxia on the MGO pathway in humans in vivo. After prehydration with glucose 2.5% solution, ten healthy males were exposed to h

SUBMITTER: Driessen RGH 

PROVIDER: S-EPMC8411911 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature