Ontology highlight
ABSTRACT:
SUBMITTER: Radka CD
PROVIDER: S-EPMC8411934 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Radka Christopher D CD Aller Stephen G SG
Acta crystallographica. Section F, Structural biology communications 20210824 Pt 9
The substrate-binding protein YfeA (also known as YPO2439 or y1897) is a polyspecific metal-binding protein that is crucial for nutrient acquisition and virulence in Yersinia pestis, the causative microbe of plague. YfeA folds into a monomeric c-clamp like other substrate-binding proteins and has two metal-binding sites (sites 1 and 2). Site 2 is a bidentate surface site capable of binding Zn and Mn atoms and is a unique feature of YfeA. Occasionally, the site 2 residues of two YfeA molecules wi ...[more]