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Nf-LO: A Scalable, Containerized Workflow for Genome-to-Genome Lift Over.


ABSTRACT: The increasing availability of new genome assemblies often comes with a paucity of associated genomic annotations, limiting the range of studies that can be performed. A common workaround is to lift over annotations from better annotated genomes. However, generating the files required to perform a lift over is computationally and labor intensive and only a limited number are currently publicly available. Here we present nf-LO (nextflow-LiftOver), a containerized and scalable Nextflow pipeline that enables lift overs within and between any species for which assemblies are available. nf-LO will consequently facilitate data interpretation across a broad range of genomic studies.

SUBMITTER: Talenti A 

PROVIDER: S-EPMC8412297 | biostudies-literature |

REPOSITORIES: biostudies-literature

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