Ontology highlight
ABSTRACT:
SUBMITTER: Arshad H
PROVIDER: S-EPMC8413896 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Arshad Hamza H Patel Zeel Z Mehrabian Mohadeseh M Bourkas Matthew E C MEC Al-Azzawi Zaid A M ZAM Schmitt-Ulms Gerold G Watts Joel C JC
The Journal of biological chemistry 20210812 3
The study of prions and the discovery of candidate therapeutics for prion disease have been facilitated by the ability of prions to replicate in cultured cells. Paradigms in which prion proteins from different species are expressed in cells with low or no expression of endogenous prion protein (PrP) have expanded the range of prion strains that can be propagated. In these systems, cells stably expressing a PrP of interest are typically generated via coexpression of a selectable marker and treatm ...[more]