Ontology highlight
ABSTRACT:
SUBMITTER: Luo T
PROVIDER: S-EPMC8414475 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Luo Taokun T Nash Geoffrey T GT Xu Ziwan Z Jiang Xiaomin X Liu Jianqiao J Lin Wenbin W
Journal of the American Chemical Society 20210823 34
The performance of photodynamic therapy (PDT) depends on the solubility, pharmacokinetic behaviors, and photophysical properties of photosensitizers (PSs). However, highly conjugated PSs with strong reactive oxygen species (ROS) generation efficiency tend to have poor solubility and aggregate in aqueous environments, leading to suboptimal PDT performance. Here, we report a new strategy to load highly conjugated but poorly soluble zinc-phthalocyanine (ZnP) PSs in the pores of a Hf<sub>12</sub>-QC ...[more]