Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma.

ABSTRACT: Exportins as the key mediators of nucleocytoplasmic transport have been identified as the controllers of the passage of numerous types of crucial cancer-related proteins. Targeting exportins in cancer cells might represent an emerging strategy in cancer intervention with the potential to affect clinical outcomes. Here, we focused on the prognostic and therapeutic values of Exportin-T (XPOT) in neuroblastoma. The correlation between the expression and prognostic values of XPOT in patients with neuroblastoma was investigated based on both published transcriptome data and our clinical data. Then, decision curve analysis (DCA) was implemented to identify a XPOT risk prediction model. In addition, RNA inference was performed to silence the expression of XPOT to further investigate the specific

SUBMITTER: Pan LJ 

PROVIDER: S-EPMC8414936 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature