Protein Amyloid Cofactors: Charged Side-Chain Arrays Meet Their Match?
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ABSTRACT: Recent advances in high-resolution structural studies of protein amyloids have revealed parallel in-register cross-β-sheets with periodic arrays of closely spaced identical residues. What do these structures tell us about the mechanisms of action of common amyloid-promoting factors, such as heparan sulfate (HS), nucleic acids, polyphosphates, anionic phospholipids, and acidic pH?
SUBMITTER: Lewkowicz E
PROVIDER: S-EPMC8415129 | biostudies-literature |
REPOSITORIES: biostudies-literature
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