Neural Field Theory of Evoked Response Sequences and Mismatch Negativity With Adaptation.
Ontology highlight
ABSTRACT:
SUBMITTER: Robinson PA
PROVIDER: S-EPMC8415526 | biostudies-literature |
REPOSITORIES: biostudies-literature
Similar Datasets
Project description:Schizophrenia is associated with cognitive deficits that reflect impaired cortical information processing. Mismatch negativity (MMN) indexes pre-attentive information processing dysfunction at the level of primary auditory cortex. This study investigates mechanisms underlying MMN impairments in schizophrenia using event-related potential, event-related spectral decomposition (ERSP) and resting state functional connectivity (rsfcMRI) approaches. For this study, MMN data to frequency, intensity and duration-deviants were analyzed from 69 schizophrenia patients and 38 healthy controls. rsfcMRI was obtained from a subsample of 38 patients and 23 controls. As expected, schizophrenia patients showed highly significant, large effect size (P=0.0004, d=1.0) deficits in MMN generation across deviant types. In ERSP analyses, responses to deviants occurred primarily the theta (4-7?Hz) frequency range consistent with distributed corticocortical processing, whereas responses to standards occurred primarily in alpha (8-12?Hz) range consistent with known frequencies of thalamocortical activation. Independent deficits in schizophrenia were observed in both the theta response to deviants (P=0.021) and the alpha-response to standards (P=0.003). At the single-trial level, differential patterns of response were observed for frequency vs duration/intensity deviants, along with At the network level, MMN deficits engaged canonical somatomotor, ventral attention and default networks, with a differential pattern of engagement across deviant types (P<0.0001). Findings indicate that deficits in thalamocortical, as well as corticocortical, connectivity contribute to auditory dysfunction in schizophrenia. In addition, differences in ERSP and rsfcMRI profiles across deviant types suggest potential differential engagement of underlying generator mechanisms.
| S-EPMC5547016 | biostudies-literature
Project description:The attunement of speech perception/discrimination to the properties of one's native language is a crucial step in speech and language development at early ages. Studying these processes in young children with a history of institutionalization is of great interest, as being raised in institutional care (IC) may lead to lags in language development. The sample consisted of 82 children, split into two age groups. The younger age group (<12 months) included 17 children from the IC and 17 children from the biological-family-care (BFC) group. The older group (>12 months) consisted of 23 children from the IC group, and 25 children from the BFC group. A double-oddball paradigm with three consonant-vowel syllables was used, utilizing native (Russian) and foreign (Hindi) languages. A Mismatch Negativity (MMN) component was elicited within a 125-225 ms time window in the frontal-central electrode. Findings demonstrate the absence of MMN effect in the younger age group, regardless of the living environment. Children in the older group are sensitive to native deviants and do not differentiate foreign language contrasts. No significant differences were observed between the IC and BFC groups for children older than 12 months, indicating that children in the IC have typical phonological processing. The results show that the MMN effect is not registered in Russian speaking children before the age of 12 months, regardless of their living environment. At 20 months of age, institutionally reared children show no evidence of delays in phonetic development despite a limited experience of language.
| S-EPMC6774417 | biostudies-literature
Project description:The visual mismatch negativity (vMMN) response is typically examined by subtracting the average response to a deviant stimulus from the response to the standard. This approach, however, can omit a critical element of the neural response, i.e., the non-phase-locked ("induced") oscillatory activity. Recent investigations of the oscillatory characteristics of the auditory mismatch negativity (aMMN) identified a crucial role for theta phase locking and power. Oscillatory characteristics of the vMMN from 39 healthy young adults were investigated in order to establish whether theta phase locking plays a similar role in the vMMN response. We explored changes in phase locking, overall post-stimulus spectral power as well as non-phase-locked spectral power compared to baseline (-300 to 0 ms). These were calculated in the frequency range of 4-50 Hz and analysed using a non-parametric cluster based analysis. vMMN was found intermittently in a broad time interval 133-584 ms post-stimulus and was associated with an early increase in theta phase locking (75-175 ms post-stimulus) that was not accompanied by an increase in theta power. Theta phase locking in the absence of an increase in theta power has been associated with the distribution and flow of information between spatially disparate neural locations. Additionally, in the 450-600 ms post-stimulus interval, deviant stimuli yielded a stronger decrease in non-phase-locked alpha power than standard stimuli, potentially reflecting a shift in attentional resources following the detection of change. The examination of oscillatory activity is crucial to the comprehensive analysis of a neural response to a stimulus, and when combined with evoked potentials (EPs) provide a more complete picture of neurocognitive processing.
| S-EPMC3729976 | biostudies-literature
Project description:The present study investigated the function of the brain activity underlying the visual mismatch negativity (vMMN) event-related potential (ERP) component. Snowflake patterns (complex stimuli) were presented as deviants and oblique bar patterns (simple stimuli) as standards, and vice versa in a passive oddball paradigm. Control (equiprobable) sequences of either complex shape patterns or oblique bar patterns with various orientations were also presented. VMMN appeared as the difference between the ERP to the oddball deviant and the ERP to the control (deviant minus control ERP difference). Apart from the shorter latency of the vMMN to the oblique bar pattern as deviant, vMMN to both deviants was similar, i.e., there was no amplitude difference. We attributed the function of the brain processes underlying vMMN to the detection of the infrequent stimulus type (also represented in memory) instead of a call for further processing (a possibility for acquiring more precise representation) of the deviant. An unexpected larger adaptation (control minus standard ERP difference) to the snowflake pattern was also obtained. We suggest that this was due to the acquisition of a more elaborate memory representation of the more complex stimulus.
| S-EPMC6557884 | biostudies-other
Project description:The mismatch negativity (MMN) component of the auditory event-related potential has become a valuable tool in cognitive neuroscience. Its reduced size in persons with schizophrenia is of unknown origin but theories proposed include links to problems in experience-dependent plasticity reliant on N-methyl-d-aspartate glutamate receptors. In this review we address the utility of this tool in revealing the nature and time course of problems in perceptual inference in this illness together with its potential for use in translational research testing animal models of schizophrenia-related phenotypes. Specifically, we review the reasons for interest in MMN in schizophrenia, issues pertaining to the measurement of MMN, its use as a vulnerability index for the development of schizophrenia, the pharmacological sensitivity of MMN and the progress in developing animal models of MMN. Within this process we highlight the challenges posed by knowledge gaps pertaining to the tool and the pharmacology of the underlying system.
| S-EPMC3866657 | biostudies-literature
Project description:The mismatch negativity (MMN) is an event related potential evoked by violations of regularity. Here, we present a model of the underlying neuronal dynamics based upon the idea that auditory cortex continuously updates a generative model to predict its sensory inputs. The MMN is then modelled as the superposition of the electric fields evoked by neuronal activity reporting prediction errors. The process by which auditory cortex generates predictions and resolves prediction errors was simulated using generalised (Bayesian) filtering--a biologically plausible scheme for probabilistic inference on the hidden states of hierarchical dynamical models. The resulting scheme generates realistic MMN waveforms, explains the qualitative effects of deviant probability and magnitude on the MMN - in terms of latency and amplitude--and makes quantitative predictions about the interactions between deviant probability and magnitude. This work advances a formal understanding of the MMN and--more generally--illustrates the potential for developing computationally informed dynamic causal models of empirical electromagnetic responses.
| S-EPMC3820518 | biostudies-literature
Project description:BackgroundMismatch negativity (MMN) is an extensively validated biomarker of cognitive function across both normative and clinical populations and has previously been localized to supratemporal auditory cortex. MMN is thought to represent a comparison of the features of the present stimulus versus a mnemonic template formed by the prior stimuli.MethodsWe used concurrent thalamic and primary auditory cortical (A1) laminar recordings in 7 macaques to evaluate the relative contributions of core (lemniscal) and matrix (nonlemniscal) thalamic afferents to MMN generation.ResultsWe demonstrated that deviance-related activity is observed mainly in matrix regions of auditory thalamus, MMN generators are most prominent in layer 1 of cortex as opposed to sensory responses that activate layer 4 first and sequentially all cortical layers, and MMN is elicited independent of the frequency tuning of A1 neuronal ensembles. Consistent with prior reports, MMN-related thalamocortical activity was strongly inhibited by ketamine.ConclusionsTaken together, our results demonstrate distinct matrix versus core thalamocortical circuitry underlying the generation of a higher-order brain response (MMN) versus sensory responses.
| S-EPMC7103554 | biostudies-literature
Project description:Autism Spectrum Conditions (ASC) are characterized by heterogeneous impairments of social reciprocity and sensory processing. Voices, similar to faces, convey socially relevant information. Whether voice processing is selectively impaired remains undetermined. This study involved recording mismatch negativity (MMN) while presenting emotionally spoken syllables dada and acoustically matched nonvocal sounds to 20 subjects with ASC and 20 healthy matched controls. The people with ASC exhibited no MMN response to emotional syllables and reduced MMN to nonvocal sounds, indicating general impairments of affective voice and acoustic discrimination. Weaker angry MMN amplitudes were associated with more autistic traits. Receiver operator characteristic analysis revealed that angry MMN amplitudes yielded a value of 0.88 (p<.001). The results suggest that people with ASC may process emotional voices in an atypical fashion already at the automatic stage. This processing abnormality can facilitate diagnosing ASC and enable social deficits in people with ASC to be predicted.
| S-EPMC4103818 | biostudies-literature
Project description:BackgroundThe Mismatch Negativity (MMN) is an event-related potential (ERP) sensitive to early auditory deviance detection and has been shown to be reduced in schizophrenia patients. Moreover, MMN amplitude reduction to duration deviant tones was found to be related to functional outcomes particularly, to neuropsychological (working memory and verbal domains) and psychosocial measures. While MMN amplitude is thought to be correlated with deficits of early sensory processing, the functional significance of MMN latency remains unclear so far. The present study focused on the investigation of MMN in relation to neuropsychological function in schizophrenia.MethodForty schizophrenia patients and 16 healthy controls underwent a passive oddball paradigm (2400 binaural tones; 88% standards [1 kHz, 80 db, 80 ms], 11% frequency deviants [1.2 kHz], 11% duration deviants [40 ms]) and a neuropsychological test-battery. Patients were assessed with regard to clinical symptoms.ResultsCompared to healthy controls schizophrenia patients showed diminished MMN amplitude and shorter MMN latency to both deviants as well as an impaired neuropsychological test performance. Severity of positive symptoms was related to decreased MMN amplitude to duration deviants. Furthermore, enhanced verbal memory performance was associated with prolonged MMN latency to frequency deviants in patients.ConclusionThe present study corroborates previous results of a diminished MMN amplitude and its association with positive symptoms in schizophrenia patients. Both, the findings of a shorter latency to duration and frequency deviants and the relationship of the latter with verbal memory in patients, emphasize the relevance of the temporal aspect of early auditory discrimination processing in schizophrenia.
| S-EPMC3989165 | biostudies-literature
Project description:One factor that is commonly thought to influence MMN amplitude is lexicality; multiple studies have shown that real-word deviants elicit larger MMNs than pseudoword deviants. Here, however, we report data from two experiments challenging this assumption. In the first experiment (N = 48), real-word deviants did not elicit more negative MMNs than pseudoword deviants; the acoustic difference between standard and deviant was identical across these comparisons. In this experiment, the pseudoword deviant [pʰa˨˩] differed from a real-word [pʰa˧˥] in tone only; therefore, to test the possibility that the lexicality effect is real but is restricted to pseudowords that differ from real words by at least one segment, we ran a second experiment which included different items and participants, and also included a control comparison in which the pseudoword ([tsʰei˨˩]) differs from all real words by at least one segment (there is no existing Mandarin morpheme pronounced [tsʰei] in any tone). In the second experiment (N = 36), both types of pseudowords failed to elicit less negative MMNs than real words. These findings, together with other recent studies failing to show lexicality effects in MMN, challenge the assumption that wordhood reliably influences MMN amplitude.
| S-EPMC7662093 | biostudies-literature