Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials.

ABSTRACT:

Objective

To evaluate possible differences between brain dopamine transporter (DAT) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals.

Background

Dopaminergic neuroimaging studies of Parkinson's disease (PD) have often used control groups formed from symptomatic patients with apparently normal striatal dopamine function. We sought to investigate whether symptomatic patients can be used to represent dopaminergically normal healthy controls.

Methods

Forty healthy elderly individuals were scanned with DAT [¹²³I]FP-CIT SPECT and compared to 69 age- and sex-matched symptomatic patients with nondegenerative conditions (including essential tremor, drug-induced parkinsonism and vascular parkinsonism).

SUBMITTER: Honkanen EA 

PROVIDER: S-EPMC8416950 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature