Transcriptome Differences in Pig Tracheal Epithelial Cells in Response to Pasteurella Multocida Infection.

ABSTRACT: Pasteurella multocida generally colonizes mammalian/bird respiratory tracts and mainly causes respiratory disorders in both humans and animals. To date, the effects of P. multocida infection on the respiratory epithelial barriers and molecules in host respiratory epithelial cells in their response to P. multocida infection are still not well-known. In this study, we used newborn pig tracheal epithelial (NPTr) cells as an in vitro model to investigate the effect of P. multocida infection on host respiratory epithelial barriers. By detecting the transepithelial electrical resistance (TEER) values of NPTr cells and the expression of several known molecules associated with cell adherens and junctions, we found that P. multocida infection disrupted the

SUBMITTER: Wang X 

PROVIDER: S-EPMC8417048 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature