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Associations of Alcohol Consumption with Cardiovascular Disease-Related Proteomic Biomarkers: The Framingham Heart Study.


ABSTRACT:

Background

Alcohol consumption and cardiovascular disease (CVD) have a complex relation.

Objectives

We examined the associations between alcohol consumption, fasting plasma proteins, and CVD risk.

Methods

We performed cross-sectional association analyses of alcohol consumption with 71 CVD-related plasma proteins, and also performed prospective association analyses of alcohol consumption and protein concentrations with 3 CVD risk factors (obesity, hypertension, and diabetes) in 6745 Framingham Heart Study (FHS) participants (mean age 49 y; 53% women).

Results

A unit increase in log10 transformed alcohol consumption (g/d) was associated with an increased risk of hypertension (HR = 1.14; 95% CI: 1.04, 1.26; P = 0.007), and decreased risks of obesity (HR = 0.80; 95% CI: 0.71, 0.91; P = 4.6 × 10-4) and diabetes (HR: 0.68; 95% CI: 0.58, 0.80; P = 5.1 × 10-6) in a median of 13-y (interquartile = 7, 14) of follow-up. We identified 43 alcohol-associated proteins in a discovery sample (n = 4348, false discovery rate <0.05) and 20 of them were significant (P <0.05/43) in an independent validation sample (n = 2397). Eighteen of the 20 proteins were inversely associated with alcohol consumption. Four of the 20 proteins demonstrated 3-way associations, as expected, with alcohol consumption and CVD risk factors. For example, a greater concentration of APOA1 was associated with higher alcohol consumption (P = 1.2 × 10-65), and it was also associated with a lower risk of diabetes (P = 8.5 × 10-6). However, several others showed unexpected 3-way associations.

Conclusions

We identified 20 alcohol-associated proteins in 6745 FHS samples. These alcohol-associated proteins demonstrated complex relations with the 3 CVD risk factors. Future studies with integration of more proteomic markers and larger sample size are warranted to unravel the complex relation between alcohol consumption and CVD risk.

SUBMITTER: Sun X 

PROVIDER: S-EPMC8417922 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Associations of Alcohol Consumption with Cardiovascular Disease-Related Proteomic Biomarkers: The Framingham Heart Study.

Sun Xianbang X   Ho Jennifer E JE   Gao He H   Evangelou Evangelos E   Yao Chen C   Huan Tianxiao T   Hwang Shih-Jen SJ   Courchesne Paul P   Larson Martin G MG   Levy Daniel D   Ma Jiantao J   Liu Chunyu C  

The Journal of nutrition 20210901 9


<h4>Background</h4>Alcohol consumption and cardiovascular disease (CVD) have a complex relation.<h4>Objectives</h4>We examined the associations between alcohol consumption, fasting plasma proteins, and CVD risk.<h4>Methods</h4>We performed cross-sectional association analyses of alcohol consumption with 71 CVD-related plasma proteins, and also performed prospective association analyses of alcohol consumption and protein concentrations with 3 CVD risk factors (obesity, hypertension, and diabetes)  ...[more]

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