The role of noradrenaline in cognition and cognitive disorders.
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ABSTRACT:
SUBMITTER: Holland N
PROVIDER: S-EPMC8418349 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
The role of noradrenaline in cognition and cognitive disorders.
Holland Negin N Robbins Trevor W TW Rowe James B JB
Brain : a journal of neurology 20210901 8
Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha and beta adrenoreceptors. Loss of these projections is common in neurodegenerative diseases and contributes to their cognitive and behavioural deficits. We review the evidence for a noradrenergic modulation of cognition in its contribution to Alzheimer's disease, Parkinson's disease and other cognitive disorders. We discuss the advances in ...[more]
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