Self-Dependent Neural Variability Predicts Recovery from Depressive Symptoms.
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SUBMITTER: Fan L
PROVIDER: S-EPMC8421703 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:The coherence of autobiographical memories plays an important role in psychological well-being, as borne out by recent studies. This study aimed to advance this understanding by assessing whether coherence predicted depressive symptoms over time in adults. Further, it aimed to specify mediators through which this association might occur, namely psychological resources of self-esteem self-efficacy, meaning in life, and optimism. A sample of 160 participants (M age = 26.4, SD = 3.2, 58.1% women) completed surveys at three time-points spaced 1 week apart. The surveys contained measures of the perceived coherence of life stories and autobiographical memories, psychological resources, and depressive symptoms. The results of a path analysis model, controlling for depressive symptoms at baseline, indicated that perceived causal coherence was the only unique predictor of later depressive symptoms, and that this occurred through positive self-concept, represented by self-esteem and self-efficacy. Limitations of the study include no examination of cultural background as a moderating factor and the short time-intervals. Overall, the findings provide further evidence that the perception of how events have unfolded and impacted on one's life and sense of self is particularly important in mitigating depressive symptoms. It extends on our understanding by showing this occurs through changes in self-concept.
| S-EPMC8044926 | biostudies-literature
Project description:The prevailing approach to the neuroscientific study of concepts is to characterize the neural pattern evoked by a given concept, averaging over any variation that might occur upon multiple retrieval attempts (e.g., across time, tasks, or people). This approach-which diverges substantially from approaches to studying conceptual processing with other methods-treats all variation as noise. Here, our goal is to determine whether variation in neural patterns evoked by semantic retrieval of a given concept is more than just measurement error, and instead reflects variation arising from contextual variability. We measured each concept's diversity of semantic contexts ("SV") by analyzing its word frequency and co-occurrence statistics in large text corpora. To measure neural variability, we conducted an fMRI study and sampled neural activity associated with each concept when it appeared in three separate, randomized contexts. We predicted that concepts with low SV would exhibit uniform activation patterns across stimulus presentations, whereas concepts with high SV would exhibit more dynamic representations over time. We observed that a concept's SV score predicted its corresponding neural variability. This finding supports a flexible, distributed organization of semantic memory, where a concept's meaning and its neural activity patterns both continuously vary across contexts.
| S-EPMC4442773 | biostudies-literature
Project description:BACKGROUND:Research suggests that depressive disorders exist on a continuum, with subthreshold symptoms causing considerable population burden and increasing individual risk of developing major depressive disorder. An alternative strategy to professional treatment of subthreshold depression is population promotion of effective self-help interventions that can be easily applied by an individual without professional guidance. The evidence for self-help interventions for depressive symptoms is reviewed in the present work, with the aim of identifying promising interventions that could inform future health promotion campaigns or stimulate further research. METHODS:A literature search for randomised controlled trials investigating self-help interventions for depressive disorders or depressive symptoms was performed using PubMed, PsycINFO and the Cochrane Database of Systematic Reviews. Reference lists and citations of included studies were also checked. Studies were grouped into those involving participants with depressive disorders or a high level of depressive symptoms, or non-clinically depressed participants not selected for depression. A number of exclusion criteria were applied, including trials with small sample sizes and where the intervention was adjunctive to antidepressants or psychotherapy. RESULTS:The majority of interventions searched had no relevant evidence to review. Of the 38 interventions reviewed, the ones with the best evidence of efficacy in depressive disorders were S-adenosylmethionine, St John's wort, bibliotherapy, computerised interventions, distraction, relaxation training, exercise, pleasant activities, sleep deprivation, and light therapy. A number of other interventions showed promise but had received less research attention. Research in non-clinical samples indicated immediate beneficial effects on depressed mood for distraction, exercise, humour, music, negative air ionisation, and singing; while potential for helpful longer-term effects was found for autogenic training, light therapy, omega 3 fatty acids, pets, and prayer. Many of the trials were poor quality and may not generalize to self-help without professional guidance. CONCLUSION:A number of self-help interventions have promising evidence for reducing subthreshold depressive symptoms. Other forms of evidence such as expert consensus may be more appropriate for interventions that are not feasible to evaluate in randomised controlled trials. There needs to be evaluation of whether promotion to the public of effective self-help strategies for subthreshold depressive symptoms could delay or prevent onset of depressive illness, reduce functional impairment, and prevent progression to other undesirable outcomes such as harmful use of substances.
| S-EPMC2542367 | biostudies-other
Project description:ObjectiveCross-sectional data have linked gut barrier abnormalities and endotoxemia with depression, even among those without gastrointestinal symptoms. This study examined longitudinal associations between endotoxemia markers and depressive symptoms, as well as the role of inflammation in this relationship.DesignAt three annual visits, 315 women (n=209 breast cancer survivors, n = 106 non-cancer patient controls, M=55 years old) completed the Center for Epidemiological Studies Depression questionnaire (CES-D) and provided blood samples to assess inflammatory markers - interleukin-6, tumor necrosis factor-alpha, and C-reactive protein - and endotoxemia markers - lipopolysaccharide-binding protein (LBP), soluble CD14 (sCD14), and their ratio.ResultsAdjusting for key demographic variables, health behaviors, visit 1 depressive symptoms, and cancer status and treatment, women with higher visit 1 LBP and LBP/sCD14 had more depressive symptoms at the two subsequent annual visits. Illustrating the notable impact, a woman at the 75th percentile for LBP or LBP/sCD14 at visit 1 was 18 % more likely to report clinically significant depressive symptoms (CES-D ≥16) at follow-up than a woman in the lowest quartile. Cancer status and treatment type did not modulate this relationship. In contrast, visit 1 depressive symptoms did not predict endotoxemia at follow-up. A significant interaction between LBP/sCD14 and inflammatory burden suggested that visit 1 endotoxemia fueled depressive symptoms only in the context of elevated inflammation.ConclusionThese results suggest that endotoxemia, combined with systemic inflammation, can drive depressive symptoms. These findings may implicate bacterial endotoxin translocation from the gut to the bloodstream in depression etiology. Interventions that reduce endotoxemia and inflammation may lessen the risk of depression.
| S-EPMC7721058 | biostudies-literature
Project description:IntroductionInterpersonal strain is linked with depressive symptoms in middle-aged adults. One possible mechanism accounting for this relation is a reduction in hope, defined as the belief in one's capacity both to reach and to generate a variety of ways to obtain goals. The strength of the strain-depressive symptoms relation is not uniform across individuals, however, pointing to the likelihood that individual differences in the ability to successfully navigate relationship strain play a role in mitigating its negative effects. One potential moderator of the strain - depressive symptoms relation is self-compassion, which encompasses the capacity to respond to one's own negative thoughts and experiences in a kind and nonjudgmental way. Although theory and empirical evidence suggest that self-compassion is protective against the impact of stress on mental health outcomes, little research has investigated how self-compassion operates in the context of relationship strain. In addition, few studies have examined psychological mechanisms by which self-compassion protects against mental health outcomes, depression in particular. Thus, this study examined 1) the extent to which hope mediates the relation between family strain and depressive symptoms, and 2) whether these indirect effects are conditional on self-compassion in a community sample of middle-aged adults.MethodsSelf-reported family strain, self-compassion, hope, and depressive symptoms were assessed in a community sample of 762 middle-aged adults aged 40-65. Follow-up measures of depressive symptoms were assessed approximately 20 months later.ResultsResults from structural equation models indicated that hope mediated the relation between family strain and depressive symptoms and the indirect effect was conditional on levels of self-compassion. For individuals high versus low in self-compassion, strain-related declines in hope predicted smaller increases in depressive symptoms.DiscussionTaken together, the findings suggest that family strain may lead individuals to experience less hope and subsequent increases in depressive symptoms. However, a self-compassionate attitude may serve as a resilience resource, weakening the hope - depressive symptoms relation, a finding that holds promise for future research on the development and refinement of self-compassion interventions.
| S-EPMC8276938 | biostudies-literature
Project description:Background/objectivesDepression screening and treatment for older adults are recommended in Age-Friendly Health Systems. Few studies have evaluated the association between depressive symptoms and postoperative functioning. We aimed to determine the association between varying levels of depressive symptoms in the preoperative setting with postoperative functional recovery.DesignProspective cohort study.SettingTwo academic hospitals in Boston, Massachusetts.ParticipantsSurgical patients aged 70 and older (N = 560).MeasurementsParticipants were assessed preoperatively and 1 year postoperatively. Preoperative evaluation included the 15-item short-form Geriatric Depression Scale (GDS). Results were categorized as low (GDS = 0-1), moderate (2-5), or high (6-15) symptom burden. Primary outcome was 1-year instrumental activities of daily living functional decline. Secondary outcomes included hospital stay longer than 5 days, discharge to post-acute care (PAC) facility, and readmission within 30 days.ResultsMean participant age was 76.6 ± 5 years, 58% were women, 81% underwent an orthopedic operation, 13% gastrointestinal, 6% vascular; 13% had functional decline at 1 year after their operation (by symptom burden: low = 5.5%; moderate = 14.8%, and high = 38.6%). After adjusting for age, sex, and comorbidity, those with moderate or high depressive symptoms demonstrated greater odds of functional decline at 1 year compared with those with a low symptom burden (moderate: adjusted odds ratio [AOR] = 2.7; 95% confidence interval [CI] = 1.3-5.3; high: AOR = 9.3; 95% CI = 4.2-20.6), discharge to PAC facility (moderate: AOR = 1.7; 95%CI = 1.2-2.6; high: AOR = 2.7; 95% CI = 1.4-5.1) but demonstrated no significant association with 30-day readmission or hospital length of stay longer than 5 days.ConclusionGreater burden of preoperative depressive symptoms is associated with increased likelihood of functional decline at 1 year after surgery and of discharge to PAC facility. Preoperative assessment of the burden of depressive symptoms in older adults undergoing elective surgery may be helpful in identifying patients at high risk of poor outcomes.
| S-EPMC7744402 | biostudies-literature
Project description:BACKGROUND:Parent-child interactions set the stage for child mental health and development. Given that maternal depressive symptoms are associated with poorer observed caregiving behaviors, examining potential cognitive mediators is important for identifying mechanisms underlying the intergenerational transmission of risk and possible targets for intervention. METHODS:We assessed depressive symptoms and levels of self-focus and psychological distancing from infant-centered verbal narratives obtained from 54 mothers, and examined caregiving behaviors in a structured interaction with their six-month-old infants. RESULTS:Higher depressive symptoms were associated with pronoun use in narratives (i.e., greater "I" and reduced "we" use), reflecting increased self-focus and psychological distancing. Further, increased self-focus was associated with lower levels of caregiver warmth, and mediated the association between depressive symptoms and caregiving warmth. LIMITATIONS:This observational study does not allow for causal interpretations. CONCLUSION:These findings suggest that the cognitive styles associated with depression interfere with the caregiving relationship, affecting behavior in parent-child interactions that may increase the risk for the intergenerational transmission of depression.
| S-EPMC6604802 | biostudies-literature
Project description:Depression is linked to increased amygdala activation to neutral and negatively valenced facial expressions. Amygdala activation may be predictive of changes in depressive symptoms over time. However, most studies in this area have focused on small, predominantly female and homogenous clinical samples. Studies are needed to examine how amygdala reactivity relates to the course of depressive symptoms dimensionally, prospectively and in populations diverse in gender, race and socioeconomic status. A total of 156 men from predominately low-income backgrounds completed an fMRI task where they viewed emotional facial expressions. Left and right amygdala reactivity to neutral, but not angry or fearful, facial expressions relative to a non-face baseline at age 20 predicted greater depressive symptoms 2 years later, controlling for age 20 depressive symptoms. Heightened bilateral amygdala reactivity to neutral facial expressions predicted increases in depressive symptoms 2 years later in a large community sample. Neutral facial expressions are affectively ambiguous and a tendency to interpret these stimuli negatively may reflect to cognitive biases that lead to increases in depressive symptoms over time. Individual differences in amygdala reactivity to neutral facial expressions appear to identify those at most risk for a more problematic course of depressive symptoms across time.
| S-EPMC4884317 | biostudies-literature
Project description:As the weakest links in information security defense are the individuals in an organizations, it is important to understand their information security behaviors. In the current study, we tested whether the neural variability pattern could predict an individual's intention to engage in information security violations. Because cognitive neuroscience methods can provide a new perspective into psychological processes without common methodological biases or social desirability, we combined an adapted version of the information security paradigm (ISP) with functional magnetic resonance imaging (fMRI) technology. While completing an adapted ISP task, participants underwent an fMRI scan. We adopted a machine learning method to build a neural variability predictive model. Consistent with previous studies, we found that people were more likely to take actions under neutral conditions than in minor violation contexts and major violation contexts. Moreover, the neural variability predictive model, including nodes within the task control, default mode, visual, salience and attention networks, can predict information security violation intentions. These results illustrate the predictive value of neural variability for information security violations and provide a new perspective for combining ISP with the fMRI technique to explore a neural predictive model of information security violation intention.
| S-EPMC11197491 | biostudies-literature
Project description:Key components of cognitive lifestyle are educational attainment, occupational complexity and engagement in cognitively stimulating leisure activities. Each of these factors is associated with experiencing fewer depressive symptoms in later life, but no study to date has examined the relationship between overall cognitive lifestyle and depressive symptoms. This task is made more complex because relatively few older participants in cross-sectional studies will be currently experiencing depression. However, many more will show evidence of a depressive thinking style that predisposes them towards depression. This study aimed to investigate the extent to which cognitive lifestyle and its individual components are associated with depressive thoughts and symptoms. Two hundred and six community-dwelling participants aged 65+ completed the depressive cognitions scale, the geriatric depression scale and the lifetime of experiences questionnaire, which assesses cognitive lifestyle. Correlational analysis indicated that each of the individual lifestyle factors-education, occupational complexity and activities in young adulthood, mid-life and later life-and the combined cognitive lifestyle score was positively associated with each other and negatively with depressive symptoms, while all except education were negatively associated with depressive thoughts. Depressive thoughts and symptoms were strongly correlated. Cognitive lifestyle score explained 4.6 % of the variance in depressive thoughts and 10.2 % of the variance in depressive symptoms. The association of greater participation in cognitive activities, especially in later life, with fewer depressive symptoms and thoughts suggests that preventive interventions aimed at increasing participation in cognitively stimulating leisure activity could be beneficial in decreasing the risk of experiencing depressive thoughts and symptoms in later life.
| S-EPMC4769311 | biostudies-other