Protecting-group-free S-glycosylation towards thioglycosides and thioglycopeptides in water.
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ABSTRACT: A facile and green S-glycosylation method has been developed featuring protecting-group-free and proceeding-in-water like enzymatic synthesis. Glycosylation of fluoride donors with thiol sugar acceptors using Ca(OH)2 as a promoter afforded various thioglycosides in good yields with exclusive stereoselectivity. This method also enabled the successful production of S-linked oligosaccharides and S-linked glycopeptides.
SUBMITTER: Zhang GL
PROVIDER: S-EPMC8423405 | biostudies-literature |
REPOSITORIES: biostudies-literature
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