T cell-oriented strategies for controlling the COVID-19 pandemic.
Ontology highlight
ABSTRACT:
SUBMITTER: Noh JY
PROVIDER: S-EPMC8424399 | biostudies-literature |
REPOSITORIES: biostudies-literature
Similar Datasets
Project description:Coronavirus disease 2019 (COVID-19) is highly contagious, and thus has become an emerging health crisis worldwide. The optimal strategies to prevent the spread of this disease are inconclusive, and therefore, the adopted measurements to combat COVID-19 varies in different countries. In mid-March and late-August 2020, we performed internet searches to collect relevant information, from sources such as the website of the World Health Organization. The epidemiological data of COVID-19 from several countries were collected and we found that Taiwan had a comparably successful story for combating the pandemic. As of mid-March, Taiwan had high rates of diagnostic testing (688.5 tests per million citizens) with a lower infection rate (49 cases, 2.1 cases per million people). As of late-August, there were 488 cases (20 cases per million people). Furthermore, Taiwanese government-guided strategies and hospital data were also reviewed. We summarized some important strategies to combat COVID-19, which include: (1) border control; (2) official media channel and press conferences; (3) name-based rationing system for medical masks; (4) TOCC-based rapid triage, outdoor clinics, and protective sampling devices; and (5) social distancing, delaying the start of new semesters, and religious assembly restriction. In conclusion, Taiwan had lower rates of COVID-19 compared with other countries, and Taiwan government-guided strategies contributed to the control of the disease's spread.
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Project description:Among over 200 COVID-19 affected countries, some are fighting to "flatten the curve", while some others are considering reopening after lockdown. It remains unclear how different reopening strategies obstruct the local virus containment and impact the economy. We develop a model with travelers across heterogeneous epicenters. A low-risk area attempts to safely reopen utilizing internal policies, such as social distancing and contact tracing, and external policies, including capacity quota, quarantine, and tests. Simulations based on the COVID-19 scenario show that external policies differ in efficacy. They can substitute each other and complement internal policies. Simultaneous relaxation of both channels may lead to a new wave of COVID-19 and large economic costs. This work highlights the importance of quantitative assessment prior to implementing reopening strategies.
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Project description:Primary outcome(s): The incidence of obstructive colorectal cancer
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Project description:A novel Corona virus (SARS-CoV-2), started in Wuhan China, caused an outbreak of viral pneumonia to subsequently spread throughout the world. Italy has been one of the most affected countries in the world and the increasing number of cases and deaths has created strong emotional reactions in people. This study has aimed at evaluating public attention to this emerging disease through the use of Google Trends. Public attention, measured as the volume of internet search activity, was correlated with Health Communication Strategies and official COVID-19 data. At the moment of the study analysis, Italy was by far the first country in terms of search volume for "coronavirus" and the highest peak of searches was reached on February 23, 2020. We have found that there was a correlation between public attention to coronavirus disease and communications from Public Health policies: we observed spikes in search volumes on the days of Presidential Decree publications. Furthermore, this attention was also correlated with Case Fatality Rate (CFR). Even if CFR data are continuously updated and can be affected by patient histories, the correlation found suggests that the increase in mortality has generated growing interest in the disease and its risk perception. This study shows that tracking searches through Google Trends as a public focus indicator is a useful tool for decision-makers in guiding communication strategies and should as well stimulate a more transparent media and policy making reporting.
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Project description:Mitigation measures and control strategies relating to novel coronavirus disease 2019 (COVID-19) have been widely applied in many countries in order to reduce the transmission of this pandemic disease. A Movement Control Order (MCO) was implemented in Malaysia starting from the March 18, 2020 as a pandemic control strategy which restricted all movement and daily outdoor activities. To investigate the impact of MCO, air pollutants: particulate matter with an aerodynamic diameter less than 10 ?m (PM10), particulate matter with an aerodynamic diameter less than 2.5 ?m (PM2.5), sulphur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3) and carbon monoxide (CO) in nine major cities in Malaysia were measured before and during the implementation of the MCO. The non-carcinogenic health risk assessments of the air pollutants are also determined using the United States Environmental Protection Agency (USEPA) Health Risk Assessment method. Overall, NO2 recorded an average percentage reduction of 40% with the highest reduction observed at Kota Kinabalu (62%). The largest reductions of PM10, PM2.5, SO2, O3 and CO were recorded at Kota Kinabalu (17%), Kuantan (9.5%), Alor Star (38%), Kota Bharu (15%), and Ipoh (27%) respectively. All cities had hazard quotient (HQ) values of <1 suggesting no non-carcinogenic health effects. The highest HQ was observed for PM2.5 during the MCO period (4.53E-02) in Kuala Lumpur. An average hazard index (HI) value of 1.44E-01 (before the MCO) and 1.40E-01 (during the MCO) showed higher human health risks before the MCO than during the MCO. This study gives confidence to regulatory bodies that the reduction of human activities significantly reduces air pollution and increases human health and so good air pollution control strategies can provide crucial impacts, especially in reducing air pollution and improving human health.
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Project description:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread worldwide.
Since then, the COVID-19 pandemic has caused a detrimental effect of the national health care system, causing a drastic reduction of the screening programs for colorectal cancer and requiring the redistribution of the hospital resources from elective surgery to the care of patients with SARS-Cov_2 infection requiring admission.
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Project description: Not available
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