Dataset Information

Reward-Seeking Deficits in Major Depression: Unpacking Appetitive Task Performance with Ex-Gaussian Response Time Variability Analysis.

ABSTRACT: Major depressive disorder (MDD) has extensive ties to motivation, including impaired response time (RT) performance. Average RT, however, conflates response speed and variability, so RT differences can be complex. Because recent studies have shown inconsistent effects of MDD on RT variability, the present research sought to unpack RT performance with several key improvements: (1) a sample of adults (n = 78; 18 MDD, 60 Control) free of antidepressant medication; (2) an unambiguously appetitive task with appealing incentives at stake; and (3) ex-Gaussian RT modeling, which can unconfound speed and variability by estimating parameters for the mean (Mu) and standard deviation (Sigma) of the normal component and the mean of the exponential component (Tau). The groups had comparable Mu and Sigma parameters, but the MDD group had a significantly larger Tau, reflecting greater intraindividual RT variability. The findings suggest that MDD's effect on average RT can stem from greater intraindividual variability, not from overall slowness. Possible mechanisms, such as impaired executive processes in MDD and difficulties maintaining stable mental representations of incentives, are considered.

SUBMITTER: Silvia PJ

PROVIDER: S-EPMC8425250 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

Reward-Seeking Deficits in Major Depression: Unpacking Appetitive Task Performance with Ex-Gaussian Response Time Variability Analysis.

Silvia Paul J PJ Eddington Kari M KM Harper Kelly L KL Burgin Chris J CJ Kwapil Thomas R TR

Motivation science 20200601 2

Major depressive disorder (MDD) has extensive ties to motivation, including impaired response time (RT) performance. Average RT, however, conflates response speed and variability, so RT differences can be complex. Because recent studies have shown inconsistent effects of MDD on RT variability, the present research sought to unpack RT performance with several key improvements: (1) a sample of adults (<i>n</i> = 78; 18 MDD, 60 Control) free of antidepressant medication; (2) an unambiguously appeti ...[more]

PMID: 34504900

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Project description:ObjectiveAttention deficit disorder (ADHD) is commonly associated with inhibitory dysfunction contributing to typical behavioral symptoms like impulsivity or hyperactivity. However, some studies analyzing intraindividual variability (IIV) of reaction times in children with ADHD (cADHD) question a predominance of inhibitory deficits. IIV is a measure of the stability of information processing and provides evidence that longer reaction times (RT) in inhibitory tasks in cADHD are due to only a few prolonged responses which may indicate deficits in sustained attention rather than inhibitory dysfunction. We wanted to find out, whether a slowing in inhibitory functioning in adults with ADHD (aADHD) is due to isolated slow responses.MethodsComputing classical RT measures (mean RT, SD), ex-Gaussian parameters of IIV (which allow a better separation of reaction time (mu), variability (sigma) and abnormally slow responses (tau) than classical measures) as well as errors of omission and commission, we examined response inhibition in a well-established GoNogo task in a sample of aADHD subjects without medication and healthy controls matched for age, gender and education.ResultsWe did not find higher numbers of commission errors in aADHD, while the number of omissions was significantly increased compared with controls. In contrast to increased mean RT, the distributional parameter mu did not document a significant slowing in aADHD. However, subjects with aADHD were characterized by increased IIV throughout the entire RT distribution as indicated by the parameters sigma and tau as well as the SD of reaction time. Moreover, we found a significant correlation between tau and the number of omission errors.ConclusionsOur findings question a primacy of inhibitory deficits in aADHD and provide evidence for attentional dysfunction. The present findings may have theoretical implications for etiological models of ADHD as well as more practical implications for neuropsychological testing in aADHD.

Dataset Information

Reward-Seeking Deficits in Major Depression: Unpacking Appetitive Task Performance with Ex-Gaussian Response Time Variability Analysis.

Publications

Reward-Seeking Deficits in Major Depression: Unpacking Appetitive Task Performance with Ex-Gaussian Response Time Variability Analysis.

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