Dataset Information

Coordination through Inhibition: Control of Stabilizing and Updating Circuits in Spatial Orientation Working Memory.

ABSTRACT: Spatial orientation memory plays a crucial role in animal navigation. Recent studies of tethered Drosophila melanogaster (fruit fly) in a virtual reality setting showed that the head direction is encoded in the form of an activity bump, i.e., localized neural activity, in the torus-shaped ellipsoid body (EB). However, how this system is involved in orientation working memory is not well understood. We investigated this question using free moving flies (D. melanogaster) in a spatial orientation memory task by manipulating two EB subsystems, C and P circuits, which are hypothesized for stabilizing and updating the activity bump, respectively. To this end, we suppressed or activated two types of inhibitory ring neurons (EIP and P) which innervate EB, and we discovered that manipulating the two inhibitory neuron types produced distinct behavioral deficits, suggesting specific roles of the inhibitory neurons in coordinating the stabilization and updating functions of the EB circuits. We further elucidate the neural mechanisms underlying such control circuits using a connectome-constrained spiking neural network model.

SUBMITTER: Han R

PROVIDER: S-EPMC8425968 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Coordination through Inhibition: Control of Stabilizing and Updating Circuits in Spatial Orientation Working Memory.

Han Rui R Huang Hsuan-Pei HP Chuang Chia-Lung CL Yen Hung-Hsiu HH Kao Wei-Tse WT Chang Hui-Yun HY Lo Chung-Chuan CC

eNeuro 20210907 5

Spatial orientation memory plays a crucial role in animal navigation. Recent studies of tethered <i>Drosophila melanogaster</i> (fruit fly) in a virtual reality setting showed that the head direction is encoded in the form of an activity bump, i.e., localized neural activity, in the torus-shaped ellipsoid body (EB). However, how this system is involved in orientation working memory is not well understood. We investigated this question using free moving flies (<i>D. melanogaster</i>) in a spatial ...[more]

PMID: 34385152

Similar Datasets

Project description:Visual-spatial working memory (VSWM) helps us to maintain and manipulate visual information in the absence of sensory input. It has been proposed that VSWM is an emergent property of the oculomotor system. In the present study we investigated the role of the oculomotor system in updating of spatial working memory representations across saccades. Participants had to maintain a location in memory while making a saccade to a different location. During the saccade the target was displaced, which went unnoticed by the participants. After executing the saccade, participants had to indicate the memorized location. If memory updating fully relies on cancellation driven by extraretinal oculomotor signals, the displacement should have no effect on the perceived location of the memorized stimulus. However, if postsaccadic retinal information about the location of the saccade target is used, the perceived location will be shifted according to the target displacement. As it has been suggested that maintenance of accurate spatial representations across saccades is especially important for action control, we used different ways of reporting the location held in memory; a match-to-sample task, a mouse click or by making another saccade. The results showed a small systematic target displacement bias in all response modalities. Parametric manipulation of the distance between the to-be-memorized stimulus and saccade target revealed that target displacement bias increased over time and changed its spatial profile from being initially centered on locations around the saccade target to becoming spatially global. Taken together results suggest that we neither rely exclusively on extraretinal nor on retinal information in updating working memory representations across saccades. The relative contribution of retinal signals is not fixed but depends on both the time available to integrate these signals as well as the distance between the saccade target and the remembered location.

Dataset Information

Coordination through Inhibition: Control of Stabilizing and Updating Circuits in Spatial Orientation Working Memory.

Publications

Coordination through Inhibition: Control of Stabilizing and Updating Circuits in Spatial Orientation Working Memory.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets