High expression of CD38 and MHC class II on CD8⁺ T cells during severe influenza disease reflects bystander activation and trogocytosis.

ABSTRACT:

Objectives

Although co-expression of CD38 and HLA-DR reflects T-cell activation during viral infections, high and prolonged CD38⁺HLA-DR⁺ expression is associated with severe disease. To date, the mechanism underpinning expression of CD38⁺HLA-DR⁺ is poorly understood.

Methods

We used mouse models of influenza A/H9N2, A/H7N9 and A/H3N2 infection to investigate mechanisms underpinning CD38⁺MHC-II⁺ phenotype on CD8⁺ T cells. To further understand MHC-II trogocytosis on murine CD8⁺ T cells as well as the significance behind the scenario, we used adoptively transferred transgenic OT-I CD8⁺ T cells and A/H3N2-SIINKEKL infection.

Results

Analysis of influenza-specific immunodomi

SUBMITTER: Jia X 

PROVIDER: S-EPMC8426257 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature