Equivalent tumor detection for early and late FAPI-46 PET acquisition.

ABSTRACT:

Introduction

Positron emission tomography (PET) using small ligands of the fibroblast activation protein (FAP) was recently introduced. However, optimal uptake time has not been defined yet. Here, we systematically compare early (~ 10 min p.i.) and late (~ 60 min p.i.) FAPI-46 imaging in patients with various types of cancer.

Methods

This is a retrospective single-institutional study. Imaging was performed at the Essen University Hospital, Germany. A total of 69 patients who underwent dual time-point imaging for either restaging (n = 52, 75%) or staging (n = 17, 25%) of cancer were included. Patients underwent PET with two acquisitions: early (mean 11 min, SD 4) and late (mean 66 min, SD 9). Mean injected activity was 148 MBq (SD 33).

Results

In total, 400 lesions wer

SUBMITTER: Ferdinandus J 

PROVIDER: S-EPMC8426301 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature