Ontology highlight
ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC8426336 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Sun Wenqiang W He Lihong L Zhang He H Tian Xiaodong X Bai Zhihua Z Sun Lei L Yang Limin L Jia Xiaojuan X Bi Yuhai Y Luo Tingrong T Cheng Gong G Fan Wenhui W Liu Wenjun W Li Jing J
Signal transduction and targeted therapy 20210909 1
As COVID-19 continues to spread rapidly worldwide and variants continue to emerge, the development and deployment of safe and effective vaccines are urgently needed. Here, we developed an mRNA vaccine based on the trimeric receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein fused to ferritin-formed nanoparticles (TF-RBD). Compared to the trimeric form of the RBD mRNA vaccine (T-RBD), TF-RBD delivered intramuscularly elicited robust and durable humoral immunity as well as a Th1-bias ...[more]