Dataset Information

Epidemiological characteristics and incubation period of SARS-CoV-2 during the 2020-2021 winter pandemic wave in North China: An observational study.

ABSTRACT: As the emergence of new variants of SARS-CoV-2 persists across the world, it is of importance to understand the distributional behavior of the incubation period of the variants for both medical research and public health policy-making. We collected the published individual-level data of 941 patients of the 2020-2021 winter pandemic wave in Hebei province, North China. We computed some epidemiological characteristics of the wave and estimated the distribution of the incubation period. We further assessed the covariate effects of sex, age, and living with a case with respect to the incubation period by a model. The infection-fatality rate was only 0.1%. The estimated median incubation period was at least 22 days, significantly extended from the estimates (ranging from 4 to 8.5 days) of the previous wave in mainland China and those ever reported elsewhere around the world. The proportion of asymptomatic patients was 90.6%. No significant covariate effect was found. The distribution of incubation period of the new variants showed a clear extension from their early generations.

SUBMITTER: Liu T

PROVIDER: S-EPMC8427015 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Epidemiological characteristics and incubation period of SARS-CoV-2 during the 2020-2021 winter pandemic wave in North China: An observational study.

Liu Tiantian T Chen Zijian Z Xu Jin J

Journal of medical virology 20210802 12

As the emergence of new variants of SARS-CoV-2 persists across the world, it is of importance to understand the distributional behavior of the incubation period of the variants for both medical research and public health policy-making. We collected the published individual-level data of 941 patients of the 2020-2021 winter pandemic wave in Hebei province, North China. We computed some epidemiological characteristics of the wave and estimated the distribution of the incubation period. We further ...[more]

PMID: 34302700

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Project description:BackgroundDuring the coronavirus disease 2019 (COVID-19) pandemic, seasonal influenza activity declined globally and remained below previous seasonal levels, but intensified in China since 2021. Preventive measures to COVID-19 accompanied by different epidemic characteristics of influenza in different regions of the world. To better respond to influenza outbreaks under the COVID-19 pandemic, we analyzed the epidemiology, antigenic and genetic characteristics, and antiviral susceptibility of influenza viruses in the mainland of China during 2020-2021.MethodsRespiratory specimens from influenza like illness cases were collected by sentinel hospitals and sent to network laboratories in Chinese National Influenza Surveillance Network. Antigenic mutation analysis of influenza virus isolates was performed by hemagglutination inhibition assay. Next-generation sequencing was used for genetic analyses. We also conducted molecular characterization and phylogenetic analysis of circulating influenza viruses. Viruses were tested for resistance to antiviral medications using phenotypic and/or sequence-based methods.ResultsIn the mainland of China, influenza activity recovered in 2021 compared with that in 2020 and intensified during the traditional influenza winter season, but it did not exceed the peak in previous years. Almost all viruses isolated during the study period were of the B/Victoria lineage and were characterized by genetic diversity, with the subgroup 1A.3a.2 viruses currently predominated. 37.8% viruses tested were antigenically similar to reference viruses representing the components of the vaccine for the 2020-2021 and 2021-2022 Northern Hemisphere influenza seasons. In addition, China has a unique subgroup of 1A.3a.1 viruses. All viruses tested were sensitive to neuraminidase inhibitors and endonuclease inhibitors, except two B/Victoria lineage viruses identified to have reduced sensitivity to neuraminidase inhibitors.ConclusionsInfluenza activity increased in the mainland of China in 2021, and caused flu season in the winter of 2021-2022. Although the diversity of influenza (sub)type decreases, B/Victoria lineage viruses show increased genetic and antigenic diversity. The world needs to be fully prepared for the co-epidemic of influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus globally.

Dataset Information

Epidemiological characteristics and incubation period of SARS-CoV-2 during the 2020-2021 winter pandemic wave in North China: An observational study.

Publications

Epidemiological characteristics and incubation period of SARS-CoV-2 during the 2020-2021 winter pandemic wave in North China: An observational study.

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