Unknown

Dataset Information

0

Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity.


ABSTRACT: Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was placed via solid-phase peptide synthesis into short 7-mer peptides. Upon iridation, the metallo-peptidic construct displayed activity in catalytic hydrogenation that outperforms small molecule analogues and which is dependent on the peptide sequence, a typical feature of metalloenzymes.

SUBMITTER: Lenzen K 

PROVIDER: S-EPMC8427656 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3984933 | biostudies-literature
| S-EPMC3374656 | biostudies-literature
| S-EPMC8213730 | biostudies-literature
| S-EPMC7766232 | biostudies-literature
| S-EPMC4981149 | biostudies-other
| S-EPMC9331725 | biostudies-literature
| S-EPMC5633786 | biostudies-literature
| S-EPMC9297864 | biostudies-literature
| S-EPMC4382702 | biostudies-literature
| S-EPMC7549093 | biostudies-literature