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Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity.


ABSTRACT: Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was placed via solid-phase peptide synthesis into short 7-mer peptides. Upon iridation, the metallo-peptidic construct displayed activity in catalytic hydrogenation that outperforms small molecule analogues and which is dependent on the peptide sequence, a typical feature of metalloenzymes.

SUBMITTER: Lenzen K 

PROVIDER: S-EPMC8427656 | biostudies-literature |

REPOSITORIES: biostudies-literature

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2020-07-03 | GSE153693 | GEO