Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity.
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ABSTRACT: Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was placed via solid-phase peptide synthesis into short 7-mer peptides. Upon iridation, the metallo-peptidic construct displayed activity in catalytic hydrogenation that outperforms small molecule analogues and which is dependent on the peptide sequence, a typical feature of metalloenzymes.
SUBMITTER: Lenzen K
PROVIDER: S-EPMC8427656 | biostudies-literature |
REPOSITORIES: biostudies-literature
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