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T-cell Redirecting Therapies for the Treatment of B-cell Lymphomas: Recent Advances.

ABSTRACT: T-cell specificity can be redirected against tumor antigens either ex vivo using engineered chimeric antigen receptor (CAR) T-cells or in vivo by bridging natural T-cells and tumor cells with bispecific T-cell engager (TCE) antibodies. Currently, four CAR T-cells have been approved by the FDA for the treatment of B-cell lymphomas, including diffuse large B cell lymphomas (DLBCL), mantle cell lymphoma (MCL), and follicular lymphoma (FL). No TCE have yet been approved for the treatment of B-cell lymphomas. However, at least four of them are in clinical development and show promising activity. Here, we review the most recent advances of CAR T-cells and TCE in the treatment of B-cell lymphomas.

SUBMITTER: Messeant O

PROVIDER: S-EPMC8428367 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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T-cell Redirecting Therapies for the Treatment of B-cell Lymphomas: Recent Advances.

Messéant Ondine O Houot Roch R Manson Guillaume G

Cancers 20210825 17

T-cell specificity can be redirected against tumor antigens either ex vivo using engineered chimeric antigen receptor (CAR) T-cells or in vivo by bridging natural T-cells and tumor cells with bispecific T-cell engager (TCE) antibodies. Currently, four CAR T-cells have been approved by the FDA for the treatment of B-cell lymphomas, including diffuse large B cell lymphomas (DLBCL), mantle cell lymphoma (MCL), and follicular lymphoma (FL). No TCE have yet been approved for the treatment of B-cell l ...[more]

PMID: 34503084

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