Effect of Tension on Human Periodontal Ligament Cells: Systematic Review and Network Analysis.

ABSTRACT: Orthodontic tooth movement is based on the remodeling of tooth-surrounding tissues in response to mechanical stimuli. During this process, human periodontal ligament cells (hPDLCs) play a central role in mechanosensing and mechanotransduction. Various in vitro models have been introduced to investigate the effect of tension on hPDLCs. They provide a valuable body of knowledge on how tension influences relevant genes, proteins, and metabolites. However, no systematic review summarizing these findings has been conducted so far. Aim of this systematic review was to identify all related in vitro studies reporting tension application on hPDLCs and summarize their findings regarding force parameters, including magnitude, frequency and duration. Expression data of genes, proteins, a

SUBMITTER: Sun C 

PROVIDER: S-EPMC8429507 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature