Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population.

ABSTRACT: Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here, we performed a comprehensive and quantitative analysis of WGD and its influence on breast cancer subtypes in patients from Taiwan and consequently highlight the genomic association between WGD and homologous recombination deficiency (HRD). A higher manifestation of WGD was reported in triple-negative breast cancer, conferring high chromosomal instability (CIN), while HER2 + tumors exhibited early WGD events, with widely varied CIN levels, compared to luminal-type tumors. An association of higher activity of de novo indel signature 2 with WGD and HRD in Taiwanese breast cancer patien

SUBMITTER: Wu CH 

PROVIDER: S-EPMC8429690 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature