Knockin' on heaven's door: Molecular mechanisms of neuronal tau uptake.

ABSTRACT: Since aggregates of the microtubule-binding protein tau were found to be the main component of neurofibrillary tangles more than 30 years ago, their contribution to neurodegeneration in Alzheimer's disease (AD) and tauopathies has become well established. Recent work shows that both tau load and its distribution in the brain of AD patients correlate with cognitive decline more closely compared to amyloid plaque deposition. In addition, the amyloid cascade hypothesis has been recently challenged because of disappointing results of clinical trials designed to treat AD by reducing beta-amyloid levels, thus fuelling a renewed interest in tau. There is now robust evidence to indicate that tau pathology can spread within the central nervous system via a prion-like mechanism following a stereotyp

SUBMITTER: De La-Rocque S 

PROVIDER: S-EPMC8432157 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature