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Protein Arginine Methyltransferase 5 Functions via Interacting Proteins

ABSTRACT: The protein arginine methyltransferases (PRMTs) are involved in such biological processes as transcription regulation, DNA repair, RNA splicing, and signal transduction, etc. In this study, we mainly focused on PRMT5, a member of the type II PRMTs, which functions mainly alongside other interacting proteins. PRMT5 has been shown to be overexpressed in a wide variety of cancers and other diseases, and is involved in the regulation of Epstein-Barr virus infection, viral carcinogenesis, spliceosome, hepatitis B, cell cycles, and various signaling pathways. We analyzed the regulatory roles of PRMT5 and interacting proteins in various biological processes above-mentioned, to elucidate for the first time the interaction between PRMT5 and its interacting proteins. This systemic analysis will enrich the biological theory and contribute to the development of novel therapies.

SUBMITTER: Liang Z

PROVIDER: S-EPMC8432624 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Protein arginine methyltransferase 7 modulates neuronal excitability by interacting with NaV1.9.

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