Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Schindler J
PROVIDER: S-EPMC8433555 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Pérez-Schindler Joaquín J Kohl Bastian B Schneider-Heieck Konstantin K Leuchtmann Aurel B AB Henríquez-Olguín Carlos C Adak Volkan V Maier Geraldine G Delezie Julien J Sakoparnig Thomas T Vargas-Fernández Elyzabeth E Karrer-Cardel Bettina B Ritz Danilo D Schmidt Alexander A Hondele Maria M Jensen Thomas E TE Hiller Sebastian S Handschin Christoph C
Proceedings of the National Academy of Sciences of the United States of America 20210901 36
Plasticity of cells, tissues, and organs is controlled by the coordinated transcription of biological programs. However, the mechanisms orchestrating such context-specific transcriptional networks mediated by the dynamic interplay of transcription factors and coregulators are poorly understood. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a prototypical master regulator of adaptive transcription in various cell types. We now uncovered a central function of the C-te ...[more]