Dataset Information

A CNN Deep Local and Global ASD Classification Approach with Continuous Wavelet Transform Using Task-Based FMRI.

ABSTRACT: Autism spectrum disorder (ASD) is a neurodegenerative disorder characterized by lingual and social disabilities. The autism diagnostic observation schedule is the current gold standard for ASD diagnosis. Developing objective computer aided technologies for ASD diagnosis with the utilization of brain imaging modalities and machine learning is one of main tracks in current studies to understand autism. Task-based fMRI demonstrates the functional activation in the brain by measuring blood oxygen level-dependent (BOLD) variations in response to certain tasks. It is believed to hold discriminant features for autism. A novel computer aided diagnosis (CAD) framework is proposed to classify 50 ASD and 50 typically developed toddlers with the adoption of CNN deep networks. The CAD system includes both local and global diagnosis in a response to speech task. Spatial dimensionality reduction with region of interest selection and clustering has been utilized. In addition, the proposed framework performs discriminant feature extraction with continuous wavelet transform. Local diagnosis on cingulate gyri, superior temporal gyrus, primary auditory cortex and angular gyrus achieves accuracies ranging between 71% and 80% with a four-fold cross validation technique. The fused global diagnosis achieves an accuracy of 86% with 82% sensitivity, 92% specificity. A brain map indicating ASD severity level for each brain area is created, which contributes to personalized diagnosis and treatment plans.

SUBMITTER: Haweel R

PROVIDER: S-EPMC8433893 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Speech enhancement algorithms are applied in multiple levels of enhancement to improve the quality of speech signals under noisy environments known as multi-channel speech enhancement (MCSE) systems. Numerous existing algorithms are used to filter noise in speech enhancement systems, which are typically employed as a pre-processor to reduce noise and improve speech quality. They may, however, be limited in performing well under low signal-to-noise ratio (SNR) situations. The speech devices are exposed to all kinds of environmental noises which may go up to a high-level frequency of noises. The objective of this research is to conduct a noise reduction experiment for a multi-channel speech enhancement (MCSE) system in stationary and non-stationary environmental noisy situations with varying speech signal SNR levels. The experiments examined the performance of the existing and the proposed MCSE systems for environmental noises in filtering low to high SNRs environmental noises (-10 dB to 20 dB). The experiments were conducted using the AURORA and LibriSpeech datasets, which consist of different types of environmental noises. The existing MCSE (BAV-MCSE) makes use of beamforming, adaptive noise reduction and voice activity detection algorithms (BAV) to filter the noises from speech signals. The proposed MCSE (DWT-CNN-MCSE) system was developed based on discrete wavelet transform (DWT) preprocessing and convolution neural network (CNN) for denoising the input noisy speech signals to improve the performance accuracy. The performance of the existing BAV-MCSE and the proposed DWT-CNN-MCSE were measured using spectrogram analysis and word recognition rate (WRR). It was identified that the existing BAV-MCSE reported the highest WRR at 93.77% for a high SNR (at 20 dB) and 5.64% on average for a low SNR (at -10 dB) for different noises. The proposed DWT-CNN-MCSE system has proven to perform well at a low SNR with WRR of 70.55% and the highest improvement (64.91% WRR) at -10 dB SNR.

Project description:UnlabelledBackgroundAutism Spectrum Conditions (ASC) are a set of pervasive neurodevelopmental conditions characterized by a wide range of lifelong signs and symptoms. Recent explanatory models of autism propose abnormal neural connectivity and are supported by studies showing decreased interhemispheric coherence in individuals with ASC. The first aim of this study was to test the hypothesis of reduced interhemispheric coherence in ASC, and secondly to investigate specific effects of task performance on interhemispheric coherence in ASC.MethodsWe analyzed electroencephalography (EEG) data from 15 participants with ASC and 15 typical controls, using Wavelet Transform Coherence (WTC) to calculate interhemispheric coherence during face and chair matching tasks, for EEG frequencies from 5 to 40 Hz and during the first 400 ms post-stimulus onset.ResultsResults demonstrate a reduction of interhemispheric coherence in the ASC group, relative to the control group, in both tasks and for all electrode pairs studied. For both tasks, group differences were generally observed after around 150 ms and at frequencies lower than 13 Hz. Regarding within-group task comparisons, while the control group presented differences in interhemispheric coherence between faces and chairs tasks at various electrode pairs (FT7-FT8, TP7-TP8, P7-P8), such differences were only seen for one electrode pair in the ASC group (T7-T8). No significant differences in EEG power spectra were observed between groups.ConclusionsInterhemispheric coherence is reduced in people with ASC, in a time and frequency specific manner, during visual perception and categorization of both social and inanimate stimuli and this reduction in coherence is widely dispersed across the brain.Results of within-group task comparisons may reflect an impairment in task differentiation in people with ASC relative to typically developing individuals.Overall, the results of this research support the value of WTC in examining the time-frequency microstructure of task-related interhemispheric EEG coherence in people with ASC.

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A CNN Deep Local and Global ASD Classification Approach with Continuous Wavelet Transform Using Task-Based FMRI.

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