Extracellular Matrix Optimization for Enhanced Physiological Relevance in Hepatic Tissue-Chips.

ABSTRACT: The cellular microenvironment is influenced explicitly by the extracellular matrix (ECM), the main tissue support biomaterial, as a decisive factor for tissue growth patterns. The recent emergence of hepatic microphysiological systems (MPS) provide the basic physiological emulation of the human liver for drug screening. However, engineering microfluidic devices with standardized surface coatings of ECM may improve MPS-based organ-specific emulation for improved drug screening. The influence of surface coatings of different ECM types on tissue development needs to be optimized. Additionally, an intensity-based image processing tool and transepithelial electrical resistance (TEER) sensor may assist in the analysis of tissue formation capacity under the influence of different ECM types. The c

SUBMITTER: Chethikkattuveli Salih AR 

PROVIDER: S-EPMC8434375 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature