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Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size.


ABSTRACT: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2, also called IMP2) plays an essential role in the development and maturation of germ cells and embryos and is a candidate gene for goat litter size, based on a previous genome-wide selective sweep analysis. In this study, the mRNA expression level of IGF2BP2 was found to be significantly higher in a single-lamb group than in a multi-lamb group. Insertions/deletions (indels) within the goat IGF2BP2 gene, including P4-Ins-13bp and P5-Del-12bp, were verified in 918 Shaanbei White Cashmere (SBWC) female goats. The minor allelic frequencies (MAFs) of P4-Ins-13bp and P5-Del-12bp loci were 0.349 and 0.295, respectively. Analysis using the Chi-square (χ2) test showed that the genotype (χ2=14.479, P=0.006) distribution of P4-Ins-13bp was significantly different between the single-lamb and multi-lamb groups. Correlation analysis demonstrated that P4-Ins-13bp was significantly associated with goat litter size (P=0.022), and individual goats with the homozygous deletion/deletion (DD) genotype produced more litters than other goats. Therefore, considered as a potential molecular marker significantly related to lambing traits, the P4-Ins-13bp mutation of the goat IGF2BP2 gene can be used in goat breeding with practical molecular marker-assisted selection (MAS) to optimize female reproduction and improve economic efficiency in the goat industry.

SUBMITTER: Xin D 

PROVIDER: S-EPMC8435346 | biostudies-literature | 2021 Sept 15

REPOSITORIES: biostudies-literature

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Insertion/deletion variants within the <i>IGF2BP2</i> gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size.

Xin Dongyun D   Bai Yangyang Y   Bi Yi Y   He Libang L   Kang Yuxin Y   Pan Chuanying C   Zhu Haijing H   Chen Hong H   Qu Lei L   Lan Xianyong X  

Journal of Zhejiang University. Science. B 20210901 9


Insulin-like growth factor 2 mRNA-binding protein 2 (<i>IGF2BP2</i>, also called <i>IMP2</i>) plays an essential role in the development and maturation of germ cells and embryos and is a candidate gene for goat litter size, based on a previous genome-wide selective sweep analysis. In this study, the mRNA expression level of <i>IGF2BP2</i> was found to be significantly higher in a single-lamb group than in a multi-lamb group. Insertions/deletions (indels) within the goat <i>IGF2BP2</i> gene, incl  ...[more]

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