Comparison of SERS pH probe responses after microencapsulation within hydrogel matrices.

ABSTRACT:

Significance

Personalized medicine requires the tracking of an individual's metabolite levels over time to detect anomalies and evaluate the body's response to medications. Implanted sensors offer effective means to continuously monitor specific metabolite levels, provided they are accurate, stable over long time periods, and do no harm.

Aim

Four types of hydrogel embedded with pH-sensitive sensors were evaluated for their accuracy, sensitivity, reversibility, longevity, dynamic response, and consistency in static versus dynamic conditions and long-term storage.

Approach

Raman spectroscopy was first used to calibrate the intensity of pH-sensitive peaks of the Raman-active hydrogel sensors in a static pH environment. The dynamic response was then assessed for hydrogels

SUBMITTER: Kotturi D 

PROVIDER: S-EPMC8435981 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature