Ontology highlight
ABSTRACT:
SUBMITTER: Han J
PROVIDER: S-EPMC8436113 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Han Jing J Chen Xin X Xu Jiawei J Chu Laili L Li Rongqing R Sun Na N Jiang Zhen Z Liu Hongyang H Ge Xing X Zheng Junnian J Yang Jing J Ikezoe Takayuki T
International journal of medical sciences 20210805 15
Aurora-A has attracted a great deal of interest as a potential therapeutic target for patients with CRC. However, the outcomes of inhibitors targeting Aurora-A are not as favorable as expected, and the basis behind the ineffectiveness remains unknown. Here, we found that signal transducer and activator of transcription 1 (STAT1) was highly expressed in colorectal cancer (CRC) xenograft mouse models that were resistant to alisertib, an Aurora-A inhibitor. Unexpectedly, we found that alisertib dis ...[more]