Optimization of single dose VSV-based COVID-19 vaccination in hamsters.

ABSTRACT: The ongoing COVID-19 pandemic has resulted in global effects on human health, economic stability, and social norms. The emergence of viral variants raises concerns about the efficacy of existing vaccines and highlights the continued need the for the development of efficient, fast-acting, and cost-effective vaccines. Here, we demonstrate the immunogenicity and protective efficacy of two vesicular stomatitis virus (VSV)-based vaccines encoding the SARS-CoV-2 spike protein either alone (VSV-SARS2) or in combination with the Ebola virus glycoprotein (VSV-SARS2-EBOV). Intranasally vaccinated hamsters showed an early CD8 ⁺ T cell response in the lungs and a greater antigen-specific IgG response, while intramuscularly vaccinated hamsters had an early CD4 ⁺ T cell and NK cell

SUBMITTER: O'Donnell KL 

PROVIDER: S-EPMC8437312 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature