Dataset Information

Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life.

ABSTRACT:

Background

The first 6 months of life are a critical window for adiposity programming. Appetite-regulating hormones (ARH) are involved in food intake regulation and might, therefore, play a role in adiposity programming. Studies examining ARH in early life are limited.

Purpose

To investigate ghrelin, peptide YY (PYY) and leptin until 6 months and associations with fat mass percentage (FM%), infant feeding and human milk macronutrients.

Procedures

In 297 term-born infants (Sophia Pluto Cohort), ghrelin (acylated), PYY and leptin were determined at 3 and 6 months, with FM% measurement by PEAPOD. Exclusive breastfeeding (BF) was classified as BF ≥ 3 months. Human milk macronutrients were analyzed (MIRIS Human Milk Analyzer).

Main findings

Ghrelin increased from 3 to 6 months (p < 0.001), while PYY decreased (p < 0.001), resulting in increasing ghrelin/PYY ratio. Leptin decreased. Leptin at 3 months was higher in girls, other ARH were similar between sexes. Leptin at 3 and 6 months correlated with FM% at both ages(R ≥ 0.321, p ≤ 0.001) and gain in FM% from 1 to 6 months(R ≥ 0.204, p = 0.001). In BF infants, also ghrelin and ghrelin/PYY ratio correlated with this gain in FM%. Exclusively BF infants had lower ghrelin and higher PYY compared to formula fed infants at 3 months (p ≤ 0.039). ARH did not correlate with macronutrients.

Conclusions

Increasing ghrelin and decreasing PYY, thus increasing ghrelin/PYY ratio, suggests an increasing orexigenic drive until 6 months. ARH were different between BF and FF infants at 3 months, but did not correlate with human milk macronutrients. Ghrelin and leptin, but not PYY, correlated with more FM development during the first 6 months, suggesting that they might be involved in adiposity programming.

SUBMITTER: de Fluiter KS

PROVIDER: S-EPMC8437841 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life.

de Fluiter Kirsten S KS Kerkhof Gerthe F GF van Beijsterveldt Inge A L P IALP Breij Laura M LM van Vark-van der Zee Leonie C LC Mulder Monique T MT Abrahamse-Berkeveld Marieke M Hokken-Koelega Anita C S ACS

European journal of nutrition 20210325 7

<h4>Background</h4>The first 6 months of life are a critical window for adiposity programming. Appetite-regulating hormones (ARH) are involved in food intake regulation and might, therefore, play a role in adiposity programming. Studies examining ARH in early life are limited.<h4>Purpose</h4>To investigate ghrelin, peptide YY (PYY) and leptin until 6 months and associations with fat mass percentage (FM%), infant feeding and human milk macronutrients.<h4>Procedures</h4>In 297 term-born infants (S ...[more]

PMID: 33768316

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Dataset Information

Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life.

Background

Purpose

Procedures

Main findings

Conclusions

Publications

Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life.

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