A Novel 29-Messenger RNA Host-Response Assay From Whole Blood Accurately Identifies Bacterial and Viral Infections in Patients Presenting to the Emergency Department With Suspected Infections: A Prospective Observational Study.

ABSTRACT:

Objectives

The rapid diagnosis of acute infections and sepsis remains a serious challenge. As a result of limitations in current diagnostics, guidelines recommend early antimicrobials for suspected sepsis patients to improve outcomes at a cost to antimicrobial stewardship. We aimed to develop and prospectively validate a new, 29-messenger RNA blood-based host-response classifier Inflammatix Bacterial Viral Non-Infected version 2 (IMX-BVN-2) to determine the likelihood of bacterial and viral infections.

Design

Prospective observational study.

Setting

Emergency Department, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Germany.

Patients

Three hundred twelve adult patients presenting to the emergency department with suspected acute infections or sep

SUBMITTER: Bauer W 

PROVIDER: S-EPMC8439671 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature