A systematic review of pathophysiology and management of familial hyperaldosteronism type 1 in pregnancy.
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ABSTRACT: Purpose
Familial hyperaldosteronism type 1 (FH-1) is a rare autosomal dominant form of primary aldosteronism, which features a marked phenotypic heterogeneity, ranging from mild to severe forms of arterial hypertension that can be complicated by stroke and cardiovascular events at a young age. As affected patients usually reach the fertile age, transmission of the disease to offspring is common. Notwithstanding this, reports of FH-1 in pregnancy are limited and there is a lack of treatment guidelines.Methods and results
We searched the PubMed and EuropePMC databases with a PICO strategy to retrieve available information on management of FH-1 patients during pregnancy. We could identify seven relevant articles, which are herein reviewed.Conclusion
Based on available information on pathophysiology and treatment of FH-1 in pregnancy, recommendations for the rational management of FH-1 in pregnancy are provided.
SUBMITTER: Sanga V
PROVIDER: S-EPMC8440273 | biostudies-literature |
REPOSITORIES: biostudies-literature
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2017-12-08 | GSE107030 | GEO
Project description:CLCN2 Chloride Channel Mutations in Familial Hyperaldosteronism Type II
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