Ontology highlight
ABSTRACT:
SUBMITTER: Dietz JV
PROVIDER: S-EPMC8441213 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Dietz Jonathan V JV Willoughby Mathilda M MM Piel Robert B RB Ross Teresa A TA Bohovych Iryna I Addis Hannah G HG Fox Jennifer L JL Lanzilotta William N WN Dailey Harry A HA Wohlschlegel James A JA Reddi Amit R AR Medlock Amy E AE Khalimonchuk Oleh O
Redox biology 20210910
Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned between the cytosol and mitochondria, with the first and final steps taking place in the mitochondrion. The pathway has been extensively studied and its biosynthetic enzymes structurally characterized to varying extents. Nevertheless, understanding of the regulation of heme synthesis and factors that influence this process in metazoans rem ...[more]